RBM33

Chr 7

RNA binding motif protein 33

Also known as: PRR8

NCBI Gene: 155435 ENSG00000184863 UniProt: Q96EV2

The protein is an RNA reader that recognizes N6-methyladenosine-containing RNAs and regulates RNA export from the nucleus and mRNA stability by promoting demethylation and recruiting export machinery. RBM33 is extremely intolerant to loss-of-function variation (pLI ~1.0, LOEUF 0.082), but no specific human disease has been definitively associated with mutations in this gene. Additional research is needed to establish clear genotype-phenotype correlations.

ResearchSummary from RefSeq, UniProt

Enables N6-methyladenosine-containing RNA reader activity and lncRNA binding activity. Involved in RNA export from nucleus and regulation of mRNA stability. Located in cytoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

0.08

LOEUF· LoF intol.

LOF

Mechanism· predicted

Some data sources returned errors (1)

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