RASL11B

Chr 4

RAS like family 11 member B

NCBI Gene: 65997ENSG00000128045UniProt: Q9BPW5OMIM: 612404

Predicted to enable G protein activity; GTP binding activity; and transforming growth factor beta receptor binding activity. Predicted to act upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.98
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.98LOEUF
pLI 0.007
Z-score 1.61
OE 0.47 (0.24–0.98)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.03Z-score
OE missense 0.76 (0.65–0.89)
107 obs / 141.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.47 (0.24–0.98)
0≤0.351.4
Missense OE?0.76 (0.65–0.89)
0≤0.61.4
Synonymous OE?1.32
0≤1.21.6
LoF obs/exp: 5 / 10.7Missense obs/exp: 107 / 141.4Syn Z: -1.94

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

RASL11B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients