RANBP6
Chr 9RAN binding protein 6
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.60LOEUF
pLI 0.000
Z-score 3.40
OE 0.38 (0.24–0.60)
More LoF-intolerant than ~75% of genes
Missense Constraint?
-0.33Z-score
OE missense 1.04 (0.97–1.11)
594 obs / 571.6 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.38 (0.24–0.60)
0≤0.351.4
Missense OE?1.04 (0.97–1.11)
0≤0.61.4
Synonymous OE?1.25
0≤1.21.6
LoF obs/exp: 13 / 34.6Missense obs/exp: 594 / 571.6Syn Z: -2.85
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
RANBP6 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools