RAB26

Chr 16

RAB26, member RAS oncogene family

Also known as: V46133

NCBI Gene: 25837ENSG00000167964UniProt: Q9ULW5OMIM: 605455

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

OMIMResearchGenerating clinical summary…
0
Active trials
12
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.59
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.59LOEUF
pLI 0.000
Z-score 0.03
OE 0.99 (0.63–1.59)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.81Z-score
OE missense 1.20 (1.05–1.37)
156 obs / 130.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.99 (0.63–1.59)
0≤0.351.4
Missense OE?1.20 (1.05–1.37)
0≤0.61.4
Synonymous OE?1.31
0≤1.21.6
LoF obs/exp: 12 / 12.1Missense obs/exp: 156 / 130.0Syn Z: -1.81

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

RAB26 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients