QDPR

Chr 4AR

quinoid dihydropteridine reductase

Also known as: DHPR, HDHPR, PKU2, SDR33C1

Dihydropteridine reductase catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin and is an essential component of pterin-dependent aromatic amino acid hydroxylating systems. Autosomal recessive mutations cause BH4-deficient hyperphenylalaninemia, which presents as atypical phenylketonuria due to insufficient biopterin production, a required cofactor for phenylalanine hydroxylase. Pathogenic variants include splicing defects, amino acid substitutions, insertions, and premature terminations that result in enzyme deficiency.

OMIMResearchSummary from RefSeq, OMIM, Mechanism
LOFmechanismARLOEUF 1.061 OMIM phenotype
Clinical SummaryQDPR
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Gene-Disease Validity (ClinGen)
dihydropteridine reductase deficiency · ARDefinitive

Definitive — sufficient evidence for diagnostic panels

Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.06LOEUF
pLI 0.000
Z-score 1.42
OE 0.59 (0.341.06)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.28Z-score
OE missense 0.93 (0.811.08)
138 obs / 147.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.59 (0.341.06)
00.351.4
Missense OE0.93 (0.811.08)
00.61.4
Synonymous OE0.98
01.21.6
LoF obs/exp: 8 / 13.7Missense obs/exp: 138 / 147.7Syn Z: 0.10
Curated Mechanism (G2P)Gene2Phenotype (DDG2P) ↗
definitiveQDPR-related hyperphenylalaninemia, BH4-deficient, CLOFAR

Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.

DN
0.7327th %ile
GOF
0.5759th %ile
LOF
0.2581th %ile

The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

QDPR · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC