PWRN2

Chr 15

Prader-Willi region non-protein coding RNA 2

Also known as: NCRNA00199

NCBI Gene: 791115ENSG00000260551
315
ClinVar variants
304
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— PWRN2
📋
ClinVar Variants
304 Pathogenic / Likely Pathogenic· 6 VUS of 315 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

315 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic296
Likely Pathogenic8
VUS6
Likely Benign2
Benign1
296
Pathogenic
8
Likely Pathogenic
6
VUS
2
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————296
Likely Pathogenic
————8
VUS
————6
Likely Benign
————2
Benign
————1
Total—313

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

PWRN2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
LncRNA PWRN2 promotes polycystic ovary syndrome progression via epigenetically reducing ATRX by recruiting LSD1.
Gong Z et al.·Reprod Biol
2023
Sulforaphane alleviates LPS-induced inflammatory injury in ARPE-19 cells by repressing the PWRN2/NF-kB pathway.
Song H et al.·Immunopharmacol Immunotoxicol
2022
Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration.
Yu X et al.·Biochem Biophys Res Commun
2021Functional
LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis.
Xin CH et al.·Eur Rev Med Pharmacol Sci
2020
Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS.
Huang X et al.·Reprod Biol Endocrinol
2018🔓 Open AccessCohort
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools