PWAR6
Chr 15Prader Willi/Angelman region RNA 6
Also known as: HBT8, PAR-6
312
ClinVar variants
307
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— PWAR6
📋
ClinVar Variants
307 Pathogenic / Likely Pathogenic· 5 VUS of 312 total submissions
Some data sources returned errors (1)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/PWAR6?content-type=application/json&expand=1
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
312 submitted variants in ClinVar
Classification Summary
Pathogenic298
Likely Pathogenic9
VUS5
298
Pathogenic
9
Likely Pathogenic
5
VUS
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 298 |
Likely Pathogenic | — | — | — | — | 9 |
VUS | — | — | — | — | 5 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 312 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
PWAR6 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype
No OMIM entries found.
External Resources
Links to major genomics databases and tools
Variant Interpretation
Population Databases
Gene Resources
Expert Curation
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
Fang H et al.·J Hematol Oncol
2024
Long Non-coding RNA Prader Willi/Angelman Region RNA 6 Suppresses Glioma Development by Modulating MicroRNA-106a-5p.
E Y et al.·Biochem Genet
2024
Mechanism of PWAR6 regulating cisplatin drug sensitivity in non-small cell lung cancer through miR-577/PHACTR1.
Tang W et al.·Gene
2024Functional
Identification and validation of a five-lncRNA prognostic signature related to Glioma using bioinformatics analysis.
Zhang C et al.·BMC Cancer
2021
LncRNA PWAR6 regulates proliferation and migration by epigenetically silencing YAP1 in tumorigenesis of pancreatic ductal adenocarcinoma.
Huang S et al.·J Cell Mol Med
2021
Translocation breakpoint disrupting the host SNHG14 gene but not coding genes or snoRNAs in typical Prader-Willi syndrome.
Lei M et al.·J Hum Genet
2019Case report
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
PWAR6 interacts with miR‑106a‑5p to regulate the osteogenic differentiation of human periodontal ligament stem cells.
Xiang J et al.·Mol Med Rep
2021🔓 Open Access
Top 5 resultsSearch Europe PMC ↗
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools