PVT1
Chr 8Pvt1 oncogene
Also known as: LINC00079, MIR1204HG, NCRNA00079, TP53LC09, onco-lncRNA-100
PVT1 encodes a long non-coding RNA that regulates the proto-oncogene MYC and is controlled by the tumor suppressor p53. Variants in this gene are associated with end-stage renal disease attributed to type 1 diabetes, while increased expression is linked to various cancers including breast cancer, ovarian cancer, acute myeloid leukemia, and Hodgkin lymphoma. The inheritance pattern for diabetes-associated variants is not specified in the available data.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
69 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 54 |
Likely Pathogenic | — | — | — | — | 1 |
VUS | — | — | — | — | 1 |
Likely Benign | — | — | — | — | 1 |
Benign | — | — | — | — | 0 |
| Total | — | 57 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
PVT1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools