PVT1

Chr 8

Pvt1 oncogene

Also known as: LINC00079, MIR1204HG, NCRNA00079, TP53LC09, onco-lncRNA-100

NCBI Gene: 5820ENSG00000249859OMIM: 165140

PVT1 encodes a long non-coding RNA that regulates the proto-oncogene MYC and is controlled by the tumor suppressor p53. Variants in this gene are associated with end-stage renal disease attributed to type 1 diabetes, while increased expression is linked to various cancers including breast cancer, ovarian cancer, acute myeloid leukemia, and Hodgkin lymphoma. The inheritance pattern for diabetes-associated variants is not specified in the available data.

OMIMResearchSummary from RefSeq
Clinical Summary— PVT1
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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PVT1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
PVT1-104aa derived from the 8q24 gene desert promotes colorectal cancer tumorigenesis.
Ma M et al.·Clin Transl Med
2026Open Access
LncRNA PVT1 activates HIF-1α/RANKL signal to promote osteoclast differentiation and inflammatory response through post-transcriptional regulation.
Lu S et al.·Biochim Biophys Acta Mol Cell Res
2026
Validation of ITPR2, DPF3, EPAS1, and PVT1-associated SNPs as biomarkers for RCC in an independent case-control cohort.
Morales-Álvarez CM et al.·Front Med (Lausanne)
2026Open AccessCohort
PVT1 lincRNA signals an androgen-dependent transcriptional activation program of oncogenes in prostate cancer cells.
Berzoti-Coelho MG et al.·Int J Cancer
2026
Retraction: Long Noncoding RNA PVT1 Promotes Melanoma Progression via Endogenous Sponging miR-26b.
Oncology Research Editorial Office.·Oncol Res
2026Open Access
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients