PTGS2
Chr 1prostaglandin-endoperoxide synthase 2
Also known as: COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Prostaglandin-endoperoxide synthase 2 (PTGS2) is an inducible cyclooxygenase enzyme that catalyzes the conversion of arachidonic acid to prostaglandins, playing a central role in inflammation and the biosynthesis of specialized pro-resolving mediators. This gene is highly constrained (pLI 0.996, LOEUF 0.263) and has an associated GeneReviews entry, though the specific disease phenotype and inheritance pattern are not provided in the available clinical data. Additional clinical information would be needed to characterize the neurogenetic disorder associated with PTGS2 mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
PTGS2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
RECRUITINGNANOVAE to Treat Knee Osteoarthritis (KOA)
NOT YET RECRUITINGEfficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
NOT YET RECRUITINGThe Seven Trial: Exploiting the Unfolded Protein Response
ACTIVE NOT RECRUITINGExpression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure
RECRUITINGExternal Resources
Links to major genomics databases and tools