PTGR3

Chr 18

prostaglandin reductase 3

Also known as: PRG-3, PTGR-3, ZADH2

NCBI Gene: 284273ENSG00000180011UniProt: Q8N4Q0

Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.27
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.27LOEUF
pLI 0.003
Z-score 1.04
OE 0.61 (0.32–1.27)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.66Z-score
OE missense 1.13 (1.01–1.26)
233 obs / 206.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.61 (0.32–1.27)
0≤0.351.4
Missense OE?1.13 (1.01–1.26)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 5 / 8.2Missense obs/exp: 233 / 206.2Syn Z: -0.66

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PTGR3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients