PRY2
Chr YPTPN13 like Y-linked 2
Also known as: PTPN13LY2
The PRY2 protein is expressed specifically in testis and is located in the nonrecombining portion of the Y chromosome within a palindromic region. No established pediatric neurogenetic diseases are currently associated with mutations in this gene based on the available information. The gene follows patrilineal inheritance as it is Y-chromosome linked.
Some data sources returned errors (1)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/PRY2?content-type=application/json&expand=1
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
101 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 72 |
Likely Pathogenic | — | — | — | — | 3 |
VUS | — | — | — | — | 12 |
Likely Benign | — | — | — | — | 8 |
Benign | — | — | — | — | 6 |
| Total | — | 101 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
PRY2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools