PRSS36

Chr 16

serine protease 36

NCBI Gene: 146547ENSG00000178226UniProt: Q5K4E3OMIM: 610560

Enables serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.07
LOEUF
GOF
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.07LOEUF
pLI 0.000
Z-score 1.17
OE 0.80 (0.61–1.07)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.92Z-score
OE missense 0.88 (0.81–0.96)
415 obs / 470.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.80 (0.61–1.07)
0≤0.351.4
Missense OE?0.88 (0.81–0.96)
0≤0.61.4
Synonymous OE?0.88
0≤1.21.6
LoF obs/exp: 33 / 41.1Missense obs/exp: 415 / 470.9Syn Z: 1.36

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PRSS36 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients