PRSS3

This gene encodes a trypsinogen, a digestive serine protease that cleaves proteins preferentially after arginine residues and has activity against Kunitz-type trypsin inhibitors. Mutations cause hereditary pancreatitis with autosomal dominant inheritance, typically presenting with recurrent episodes of abdominal pain beginning in childhood or adolescence. The gene is not highly constrained against loss-of-function variants, consistent with pancreatitis being the primary manifestation rather than a severe multisystem disorder.