PRSS3

Chr 9

serine protease 3

ENSG00000010438UniProt: P35030

Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors

ResearchGenerating clinical summary…
0
Active trials
17
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.90
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (2)

ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.90LOEUF
pLI 0.000
Z-score -1.24
OE 1.41 (0.93–1.90)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.03Z-score
OE missense 1.01 (0.89–1.15)
159 obs / 157.8 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.41 (0.93–1.90)
0≤0.351.4
Missense OE?1.01 (0.89–1.15)
0≤0.61.4
Synonymous OE?0.77
0≤1.21.6
LoF obs/exp: 15 / 10.6Missense obs/exp: 159 / 157.8Syn Z: 1.44

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PRSS3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients