PRSS2

Chr 7AD

serine protease 2

Also known as: TRY2, TRY8, TRYP2

NCBI Gene: 5645ENSG00000275896UniProt: P07478

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

Primary Disease Associations & Inheritance

{Pancreatitis, chronic, protection against}MIM #167800
AD
28
ClinVar variants
21
Pathogenic / LP
—
pLI score
1
Active trials
Clinical Summary— PRSS2
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 1 VUS of 28 total submissions
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

28 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic20
Likely Pathogenic1
VUS1
Likely Benign4
Benign2
20
Pathogenic
1
Likely Pathogenic
1
VUS
4
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————20
Likely Pathogenic
————1
VUS
————1
Likely Benign
————4
Benign
————2
Total—28

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

PRSS2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM

{Pancreatitis, chronic, protection against}

MIM #167800

Molecular basis of disorder known

Autosomal dominant
📖
GeneReview available — PRSS2
Authoritative clinical overview · NCBI Bookshelf · Recommended first read
Open GeneReview ↗
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Hereditary chronic pancreatitis.
Teich N et al.·Best Pract Res Clin Gastroenterol
2008Review
Hereditary chronic pancreatitis.
Rosendahl J et al.·Orphanet J Rare Dis
2007Review
Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.
Zou WB et al.·Hum Genet
2022Review
Genetic aspects of pancreatitis.
Whitcomb DC·Annu Rev Med
2010Review
The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis.
Masson E et al.·Pancreatology
2023Meta-analysis
Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR).
Bruschi M et al.·J Transl Med
2025
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.
Witt H et al.·Nat Genet
2006
Improved NGS variant calling tool for the PRSS1-PRSS2 locus.
Lou H et al.·Gut
2023
Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.
Avanthi SU et al.·J Gastroenterol Hepatol
2015
Copy number variations in chronic pancreatitis.
Chen JM et al.·Cytogenet Genome Res
2008Review
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Pancreas CancerPeutz-Jeghers Syndrome (PJS)Gene Mutation

The Cancer of the Pancreas Screening-5 CAPS5)Study

RECRUITING
NCT02000089Phase PHASE3Johns Hopkins UniversityStarted 2014-01-06
SecretinMRITumor marker gene test with CA19-9

External Resources

Links to major genomics databases and tools