PRR3

Chr 6

proline rich 3

Also known as: CAT56

NCBI Gene: 80742ENSG00000204576UniProt: Q9NQS3

Enables RNA binding activity. Predicted to be involved in positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.10
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.10LOEUF
pLI 0.001
Z-score 1.35
OE 0.56 (0.30–1.10)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.78Z-score
OE missense 0.79 (0.67–0.94)
88 obs / 111.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.56 (0.30–1.10)
0≤0.351.4
Missense OE?0.79 (0.67–0.94)
0≤0.61.4
Synonymous OE?1.10
0≤1.21.6
LoF obs/exp: 6 / 10.8Missense obs/exp: 88 / 111.2Syn Z: -0.52

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PRR3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients