PRP4K

Chr 6

pre-mRNA processing factor kinase PRP4K

Also known as: PR4H, PRP4, PRP4H, PRPF4B, Prp4B, dJ1013A10.1

NCBI Gene: 8899ENSG00000112739UniProt: Q13523

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

92
ClinVar variants
43
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— PRP4K
📋
ClinVar Variants
43 Pathogenic / Likely Pathogenic· 40 VUS of 92 total submissions
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

92 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic38
Likely Pathogenic5
VUS40
Likely Benign7
Benign2
38
Pathogenic
5
Likely Pathogenic
40
VUS
7
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
38
0
38
Likely Pathogenic
0
0
5
0
5
VUS
0
38
2
0
40
Likely Benign
0
2
2
3
7
Benign
0
0
0
2
2
Total04047592

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

PRP4K · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy.
Mathavarajah S et al.·Cell Rep
2025
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
Schneider M et al.·Nat Struct Mol Biol
2010
Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.
Cho YS et al.·Nat Commun
2018
PRP4K is a HER2-regulated modifier of taxane sensitivity.
Corkery DP et al.·Cell Cycle
2015
The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth.
Xie Z et al.·Cell Death Differ
2025
Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4).
Shehzad A et al.·Chem Biol Interact
2013Functional
Subcellular Translocation of Yorkie through the PRP4K-CRM1 Axis Regulates Antimicrobial Peptides Transcription and Defense against Bacterial Infection in Crab.
Qin Y et al.·J Immunol
2023
Haploinsufficient tumor suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition.
Clarke LE et al.·FASEB J
2021
Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
Dellaire G et al.·Mol Cell Biol
2002
Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.
Corkery DP et al.·Oncogene
2018
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Tinker, Tailor, Tumour Suppressor: The Many Functions of PRP4K.
Habib EB et al.·Front Genet
2022🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools