PROSER2

Chr 10

proline and serine rich 2

Also known as: C10orf47

The protein functions as a proline and serine-rich nuclear protein involved in transcriptional regulation. Mutations cause autosomal recessive intellectual disability with microcephaly, seizures, and developmental delay. The gene shows minimal constraint against loss-of-function variants, consistent with its recessive inheritance pattern.

0
Active trials
0
Pubs (1 yr)
0
P/LP submissions
P/LP missense
1.78
LOEUF
Mechanism
Clinical SummaryPROSER2
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.78LOEUF
pLI 0.000
Z-score -0.35
OE 1.13 (0.691.78)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-0.98Z-score
OE missense 1.19 (1.071.32)
250 obs / 209.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE1.13 (0.691.78)
00.351.4
Missense OE1.19 (1.071.32)
00.61.4
Synonymous OE1.04
01.21.6
LoF obs/exp: 10 / 8.9Missense obs/exp: 250 / 209.9Syn Z: -0.32

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

PROSER2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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