PRMT8
Chr 12protein arginine methyltransferase 8
Also known as: HRMT1L3, HRMT1L4
PRMT8 encodes a membrane-associated arginine methyltransferase that catalyzes monomethylation and asymmetric dimethylation of proteins including myelin basic protein and histones, playing roles in DNA repair, RNA transcription, and signal transduction. The gene is highly constrained against loss-of-function variants (pLI 0.98, LOEUF 0.30), but no specific disease associations have been established in the provided data. An inheritance pattern cannot be determined without identified disease-causing mutations.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
ClinVar Variant Classifications
114 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 59 | 0 | 59 |
Likely Pathogenic | 0 | 0 | 4 | 0 | 4 |
VUS | 0 | 27 | 9 | 0 | 36 |
Likely Benign | 0 | 1 | 1 | 0 | 2 |
Benign | 0 | 0 | 0 | 3 | 3 |
| Total | 0 | 28 | 73 | 3 | 104 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
PRMT8 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools