PRLHR

Chr 10

prolactin releasing hormone receptor

Also known as: GPR10, GR3, PrRPR

NCBI Gene: 2834ENSG00000119973UniProt: P49683OMIM: 600895

Predicted to enable neuropeptide receptor activity. Predicted to be involved in feeding behavior and neuropeptide signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; adult feeding behavior; and hormone metabolic process. Located in cilium. Implicated in hypertension. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
1
Active trials
—
Pubs (1 yr)
—
P/LP submissions
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P/LP missense
1.48
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.48LOEUF
pLI 0.000
Z-score 0.55
OE 0.80 (0.45–1.48)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.41Z-score
OE missense 1.07 (0.97–1.19)
250 obs / 232.6 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.80 (0.45–1.48)
0≤0.351.4
Missense OE?1.07 (0.97–1.19)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 7 / 8.8Missense obs/exp: 250 / 232.6Syn Z: 0.47

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PRLHR · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients