PRLH

Chr 2

prolactin releasing hormone

Also known as: PRH, PRRP

NCBI Gene: 51052 ENSG00000071677 UniProt: P81277 OMIM: 602663

Predicted to enable neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; feeding behavior; and response to peptide hormone. Predicted to act upstream of or within several processes, including reduction of food intake in response to dietary excess; response to glucose; and response to insulin. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jun 2026]

OMIM Research

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.86

LOEUF

Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.86LOEUF

pLI 0.108

Z-score 0.26

OE 0.75 (0.23–1.86)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

-0.64Z-score

OE missense 1.23 (1.02–1.48)

77 obs / 62.8 exp

Tolerant

Tolerant to missense variation

Observed / Expected Ratios?

LoF OE?0.75 (0.23–1.86)

0≤0.351.4

Missense OE?1.23 (1.02–1.48)

0≤0.61.4

Synonymous OE?1.30

0≤1.21.6

LoF obs/exp: 1 / 1.3Missense obs/exp: 77 / 62.8Syn Z: -1.20

Background carrier burden — how many people carry a rare variant somewhere in PRLH?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 160

153 rare PASS variants

Rare truncating (LoF)

1 in 740

27 rare PASS variants

Rare synonymous (reference)

1 in 470

72 rare PASS variants

Rare missense and truncating variants are carried at similar rates in PRLH; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 190	1 in 2,900
South Asian	~43k	1 in 370	1 in 2,600
Remaining (unassigned)	~30k	1 in 190	1 in 620
European (Finnish)	~27k	1 in 1,000	≈ 1 in 6,000
Admixed American	~22k	1 in 330	1 in 4,200
African / African American	~21k	1 in 150	≈ 1 in 6,400
East Asian	~20k	1 in 450	≈ 1 in 4,800
Ashkenazi Jewish	~13k	≈ 1 in 6,500	none seen
Middle Eastern	~2,884	1 in 260	≈ 1 in 2,800

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 2 coding exons well covered in gnomAD exomes and genomes.? see exons ↓