PRH2

Chr 12

proline rich protein HaeIII subfamily 2

Also known as: PRP-1/PRP-2, Pr, pr1/Pr2

NCBI Gene: 5555 ENSG00000134551 UniProt: P02810 OMIM: 168790

This gene encodes proline-rich protein 2, a salivary glycoprotein that acts as a potent inhibitor of calcium phosphate crystal growth, providing protective and reparative functions for dental enamel integrity. The gene shows low constraint to loss-of-function variants (pLI 0.01, LOEUF 1.68), and certain alleles are associated with increased susceptibility to dental caries with presumed autosomal recessive inheritance. This gene primarily affects dental health rather than neurological function.

OMIM ResearchSummary from RefSeq, UniProt

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.68

LOEUF

Multiple*

Mechanism· predicted