PRDX3
Chr 10ADARperoxiredoxin 3
Also known as: AOP-1, AOP1, HBC189, MER5, PPPCD, PRO1748, SCAR32, SP-22
This gene encodes a mitochondrial thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides, protecting cells against oxidative stress. Mutations cause corneal dystrophy with punctiform and polychromatic pre-Descemet changes and spinocerebellar ataxia, autosomal recessive 32, affecting both ocular and cerebellar systems. The gene shows both autosomal dominant and autosomal recessive inheritance patterns depending on the associated phenotype.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
PRDX3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools