PRDM16-DT

Chr 1

PRDM16 divergent transcript

Also known as: LINC00982, lnc-dPrdm16

I cannot provide a clinical gene summary for PRDM16-DT as no functional, phenotypic, or inheritance pattern information has been provided in the data. PRDM16-DT appears to be a long non-coding RNA transcript associated with the PRDM16 locus, but without supporting clinical and molecular data, I cannot make claims about its role in human disease.

Research

ResearchGenerating clinical summary…

Clinical Summary— PRDM16-DT

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ClinVar Variants

3 VUS of 16 total submissions

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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

16 submitted variants in ClinVar

ClinVar

Classification Summary

VUS3

Likely Benign9

Benign3

VUS

Likely Benign

Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	Missense + Inframe	Non-coding	Synonymous	Total
Pathogenic	0	0	0	0
Likely Pathogenic	0	0	0	0
VUS	2	1	0	3
Likely Benign	0	6	3	9
Benign	0	3	0	3
Total	2	10	3	15

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

54 pathogenic / likely-pathogenic (of 64) ClinVar copy-number / structural variants overlap PRDM16-DT — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →