PRAMEF25

Chr 1

PRAME family member 25

NCBI Gene: 441873ENSG00000229571UniProt: A6NGN4

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.95
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.95LOEUF
pLI 0.000
Z-score -1.43
OE 1.72 (0.91–1.95)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.35Z-score
OE missense 1.45 (1.24–1.71)
102 obs / 70.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.72 (0.91–1.95)
0≤0.351.4
Missense OE?1.45 (1.24–1.71)
0≤0.61.4
Synonymous OE?1.30
0≤1.21.6
LoF obs/exp: 8 / 4.7Missense obs/exp: 102 / 70.2Syn Z: -1.21

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PRAMEF25 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients