PPIAL4F

Chr 1

peptidylprolyl isomerase A like 4F

NCBI Gene: 728945ENSG00000279782UniProt: P0DN26

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

48
ClinVar variants
42
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— PPIAL4F
📋
ClinVar Variants
42 Pathogenic / Likely Pathogenic· 4 VUS of 48 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

48 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic37
Likely Pathogenic5
VUS4
Benign2
37
Pathogenic
5
Likely Pathogenic
4
VUS
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————37
Likely Pathogenic
————5
VUS
————4
Likely Benign
————0
Benign
————2
Total—48

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

PPIAL4F · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for PPIAL4F

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools