POLR3G

Chr 5

RNA polymerase III subunit G

Also known as: C31, RPC32, RPC7

NCBI Gene: 10622ENSG00000113356UniProt: O15318

Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]

0
Active trials
29
Pathogenic / LP
78
ClinVar variants
6
Pubs (1 yr)
0.4
Missense Z
1.73
LOEUF
Clinical Summary— POLR3G
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
29 Pathogenic / Likely Pathogenic· 46 VUS of 78 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint
1.73LOEUF
pLI 0.000
Z-score -0.45
OE 1.14 (0.75–1.73)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.35Z-score
OE missense 0.91 (0.77–1.07)
104 obs / 114.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE1.14 (0.75–1.73)
0≤0.351.4
Missense OE0.91 (0.77–1.07)
0≤0.61.4
Synonymous OE0.94
0≤1.21.6
LoF obs/exp: 14 / 12.3Missense obs/exp: 104 / 114.6Syn Z: 0.32

ClinVar Variant Classifications

78 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic25
Likely Pathogenic4
VUS46
Likely Benign3
25
Pathogenic
4
Likely Pathogenic
46
VUS
3
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
25
0
25
Likely Pathogenic
0
0
4
0
4
VUS
0
41
5
0
46
Likely Benign
0
3
0
0
3
Benign
0
0
0
0
0
Total04434078

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

POLR3G · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients