POLG-DT

Chr 15

POLG divergent transcript

NCBI Gene: 119545629 ENSG00000261441

I notice that no information has been provided below your request about the POLG-DT gene - there's no data about protein function, associated diseases, inheritance patterns, or any other details that you've instructed me to use exclusively. Additionally, I cannot find POLG-DT as a standard gene symbol in major genetic databases. Could you please provide the specific information about this gene that you'd like me to use for the clinical summary, or clarify if you meant a different gene symbol (such as POLG)?

Research

ResearchGenerating clinical summary…

Clinical Summary— POLG-DT

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ClinVar Variants

5 VUS of 11 total submissions

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Clinical Trials

1 active or recruiting trial — potential therapeutic options may be available

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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

11 submitted variants in ClinVar

ClinVar

Classification Summary

VUS5

Likely Benign3

Benign2

VUS

Likely Benign

Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	LoF	Non-coding	Total
Pathogenic	0	0	0
Likely Pathogenic	0	0	0
VUS	1	4	5
Likely Benign	0	3	3
Benign	0	2	2
Total	1	9	10

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

11 pathogenic / likely-pathogenic (of 11) ClinVar copy-number / structural variants overlap POLG-DT — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →