POFUT4

Chr 10

protein O-fucosyltransferase 4

Also known as: FUCTXI, FUT11

NCBI Gene: 170384ENSG00000196968UniProt: Q495W5OMIM: 616932

Enables peptide-O-fucosyltransferase activity. Involved in N-glycan processing and positive regulation of protein secretion. Is active in endoplasmic reticulum. Implicated in stomach cancer. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
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P/LP submissions
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P/LP missense
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LOEUF
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Mechanism
Some data sources returned errors (1)

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

POFUT4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients