PNLIPRP1

Chr 10

pancreatic lipase related protein 1

Also known as: PLRP1

NCBI Gene: 5407ENSG00000187021UniProt: P54315OMIM: 604422

Predicted to enable calcium ion binding activity; glycerophospholipid phospholipase A1 activity; and lipoprotein lipase activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to be located in extracellular region. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.23
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.23LOEUF
pLI 0.000
Z-score 0.64
OE 0.86 (0.62–1.23)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.08Z-score
OE missense 1.01 (0.92–1.12)
264 obs / 260.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.86 (0.62–1.23)
0≤0.351.4
Missense OE?1.01 (0.92–1.12)
0≤0.61.4
Synonymous OE?1.10
0≤1.21.6
LoF obs/exp: 22 / 25.5Missense obs/exp: 264 / 260.2Syn Z: -0.78

ClinVar

No ClinVar data available.

Protein Context — Lollipop Plot

PNLIPRP1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients