PIM3
Chr 22Pim-3 proto-oncogene, serine/threonine kinase
The PIM3 gene encodes a serine/threonine protein kinase that regulates cell survival, protein synthesis, and energy metabolism through phosphorylation of multiple targets including BAD and regulation of MYC transcriptional activity. PIM3 is highly constrained against loss-of-function variants in the general population, but pathogenic variants causing Mendelian disease have not been clearly established in clinical databases. The gene's role in preventing apoptosis and promoting cell survival suggests potential for developmental or neurological phenotypes if disease-causing variants are identified.
Some data sources returned errors (1)
ncbi: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
PIM3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools