PIM3

Chr 22

Pim-3 proto-oncogene, serine/threonine kinase

Also known as: pim-3

NCBI Gene: 415116ENSG00000198355UniProt: Q86V86

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

196
ClinVar variants
138
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— PIM3
📋
ClinVar Variants
138 Pathogenic / Likely Pathogenic· 47 VUS of 196 total submissions
Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 502

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

196 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic136
Likely Pathogenic2
VUS47
Likely Benign1
Benign5
136
Pathogenic
2
Likely Pathogenic
47
VUS
1
Likely Benign
5
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
136
0
136
Likely Pathogenic
0
0
2
0
2
VUS
0
38
9
0
47
Likely Benign
0
1
0
0
1
Benign
0
3
1
1
5
Total0421481191

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

PIM3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
ONCOGENE PIM3; PIM3
MIM #610580 · *
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells.
Marayati R et al.·Cancer Gene Ther
2022
The presence of PIM3 increases hepatoblastoma tumorigenesis and tumor initiating cell phenotype and is associated with decreased patient survival.
Stafman LL et al.·J Pediatr Surg
2019
PIM1 kinase and its diverse substrate in solid tumors.
Choudhury R et al.·Cell Commun Signal
2024Review
Targeting Pim kinases in hematological cancers: molecular and clinical review.
Bellon M et al.·Mol Cancer
2023Review
Effects of PIM3 in prognosis of colon cancer.
Zhou Y et al.·Clin Transl Oncol
2021
Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceus.
Zang H et al.·J Orthop Surg Res
2025
PIM kinase inhibitors: Structural and pharmacological perspectives.
Asati V et al.·Eur J Med Chem
2019Review
High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms.
Motylewska E et al.·Endocr Pathol
2020
Small molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent update.
Arunesh GM et al.·Expert Opin Ther Pat
2014Review
Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.
Gomez F et al.·Cancer Res Commun
2023
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools