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PIERS
Chr 3ARlaminin subunit beta 2
Also known as: LAMS, NPHS5, PIERS
The LAMB2 gene encodes the laminin beta-2 chain, a glycoprotein component of basement membranes that is particularly enriched at neuromuscular junctions and in kidney glomeruli. Mutations cause Pierson syndrome, an autosomal recessive disorder characterized by congenital nephrotic syndrome and ocular abnormalities including microcoria. This condition typically presents in the neonatal period with severe renal dysfunction and distinctive eye findings.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/PIERS?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
PIERS · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
External Resources
Links to major genomics databases and tools