PF4

Chr 4

platelet factor 4

Also known as: CXCL4, PF-4, SCYB4

The protein functions as a CXC chemokine released from activated platelets that regulates platelet aggregation, hematopoiesis, immune cell migration, and has anticoagulant effects through heparin binding. Mutations cause autosomal dominant thrombocytopenia-5, a bleeding disorder characterized by reduced platelet counts and abnormal platelet function. The gene shows low constraint to loss-of-function variation, suggesting that complete loss of protein function may be tolerated.

OMIMResearchSummary from RefSeq, UniProt
DNmechanismLOEUF 1.73
Clinical SummaryPF4
Population Constraint (gnomAD)
Low constraint (pLI 0.04) — loss-of-function variants are relatively tolerated in the population.
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Clinical Trials
2 active or recruiting trials — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.73LOEUF
pLI 0.043
Z-score 0.53
OE 0.67 (0.271.73)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.26Z-score
OE missense 0.90 (0.721.14)
51 obs / 56.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.67 (0.271.73)
00.351.4
Missense OE0.90 (0.721.14)
00.61.4
Synonymous OE0.96
01.21.6
LoF obs/exp: 2 / 3.0Missense obs/exp: 51 / 56.5Syn Z: 0.18
DN
0.78top 25%
GOF
0.5660th %ile
LOF
0.1697th %ile

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

PF4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
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