PDCD1LG2

Chr 9

programmed cell death 1 ligand 2

Also known as: B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2

NCBI Gene: 80380ENSG00000197646UniProt: Q9BQ51

Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
2
Active trials
51
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.28
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.28LOEUF
pLI 0.000
Z-score 0.86
OE 0.73 (0.44–1.28)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.67Z-score
OE missense 1.16 (1.02–1.31)
168 obs / 145.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.73 (0.44–1.28)
0≤0.351.4
Missense OE?1.16 (1.02–1.31)
0≤0.61.4
Synonymous OE?1.13
0≤1.21.6
LoF obs/exp: 9 / 12.2Missense obs/exp: 168 / 145.4Syn Z: -0.79

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PDCD1LG2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients