PCGEM1

Chr 2

PCGEM1 prostate-specific transcript

Also known as: LINC00071, NCRNA00071, PCAT9

NCBI Gene: 64002ENSG00000227418

This gene produces a long non-coding RNA that is overexpressed in prostate cancer and may act a marker for tumor progression. This RNA may act a negative regulator of apoptosis, and may promote activity of androgen receptor and Myc. [provided by RefSeq, Dec 2017]

31
ClinVar variants
28
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— PCGEM1
📋
ClinVar Variants
28 Pathogenic / Likely Pathogenic· 2 VUS of 31 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

31 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic27
Likely Pathogenic1
VUS2
Likely Benign1
27
Pathogenic
1
Likely Pathogenic
2
VUS
1
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————27
Likely Pathogenic
————1
VUS
————2
Likely Benign
————1
Benign
————0
Total—31

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

PCGEM1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Biomarkers of Aggressive Prostate Cancer at Diagnosis.
Boehm BE et al.·Int J Mol Sci
2023Review
Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
Li J et al.·Orthop Surg
2023
Small interfering RNA target for long noncoding RNA PCGEM1 increases the sensitivity of LNCaP cells to baicalein.
Han Z et al.·Anat Rec (Hoboken)
2020
Regulation of androgen receptor splice variant AR3 by PCGEM1.
Zhang Z et al.·Oncotarget
2016
LncRNA PCGEM1 induces proliferation and migration in non-small cell lung cancer cells through modulating the miR-590-3p/SOX11 axis.
Wen H et al.·BMC Pulm Med
2021
lncRNA PCGEM1 strengthens anti-inflammatory and lung protective effects of montelukast sodium in children with cough-variant asthma.
Xu Z et al.·Braz J Med Biol Res
2020
Long non-coding RNA: A newly deciphered "code" in prostate cancer.
Zhang A et al.·Cancer Lett
2016Review
The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo.
Parolia A et al.·Mol Cancer
2015
Circulating long non-coding RNA PCGEM1 as a novel biomarker for gastric cancer diagnosis.
Jiang H et al.·Pathol Res Pract
2019
Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?
Walsh AL et al.·Trends Mol Med
2014Review
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools