PATE4

Chr 11

prostate and testis expressed 4

Also known as: PATE-B

NCBI Gene: 399968ENSG00000237353UniProt: P0C8F1

Enables acetylcholine receptor regulator activity. Involved in regulation of neurotransmitter receptor activity. Located in acrosomal vesicle and obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.85
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.85LOEUF
pLI 0.001
Z-score -0.09
OE 1.05 (0.50–1.85)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.18Z-score
OE missense 0.93 (0.72–1.20)
43 obs / 46.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.05 (0.50–1.85)
0≤0.351.4
Missense OE?0.93 (0.72–1.20)
0≤0.61.4
Synonymous OE?0.92
0≤1.21.6
LoF obs/exp: 4 / 3.8Missense obs/exp: 43 / 46.4Syn Z: 0.25

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PATE4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients