PARVG
Chr 22parvin gamma
Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.90LOEUF
pLI 0.000
Z-score 1.91
OE 0.54 (0.34–0.90)
Typical tolerance to LoF variation
Missense Constraint?
0.28Z-score
OE missense 0.94 (0.83–1.07)
179 obs / 189.9 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.54 (0.34–0.90)
0≤0.351.4
Missense OE?0.94 (0.83–1.07)
0≤0.61.4
Synonymous OE?0.99
0≤1.21.6
LoF obs/exp: 11 / 20.3Missense obs/exp: 179 / 189.9Syn Z: 0.08
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
PARVG · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools