PARP10

Chr 8

poly(ADP-ribose) polymerase family member 10

Also known as: ARTD10

NCBI Gene: 84875ENSG00000178685UniProt: Q53GL7OMIM: 609564

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

OMIMResearchGenerating clinical summary…
0
Active trials
18
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.74
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.74LOEUF
pLI 0.000
Z-score 2.82
OE 0.50 (0.35–0.74)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.55Z-score
OE missense 0.83 (0.77–0.89)
532 obs / 642.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.50 (0.35–0.74)
0≤0.351.4
Missense OE?0.83 (0.77–0.89)
0≤0.61.4
Synonymous OE?0.91
0≤1.21.6
LoF obs/exp: 19 / 37.7Missense obs/exp: 532 / 642.6Syn Z: 1.19

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PARP10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients