PABPC4L

Chr 4

poly(A) binding protein cytoplasmic 4 like

NCBI Gene: 132430ENSG00000254535UniProt: P0CB38

Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be involved in positive regulation of gene expression. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.05
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.05LOEUF
pLI 0.001
Z-score 1.45
OE 0.56 (0.32–1.05)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.47Z-score
OE missense 0.73 (0.65–0.83)
175 obs / 239.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.56 (0.32–1.05)
0≤0.351.4
Missense OE?0.73 (0.65–0.83)
0≤0.61.4
Synonymous OE?0.77
0≤1.21.6
LoF obs/exp: 7 / 12.6Missense obs/exp: 175 / 239.0Syn Z: 1.70

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

PABPC4L · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients