P3R3URF-PIK3R3
Chr 1P3R3URF-PIK3R3 readthrough
Also known as: LOC110117498-PIK3R3
This locus represents a naturally occurring readthrough transcript between neighboring genes that encodes a fusion protein sharing sequence identity with the individual gene products. No established disease associations or inheritance patterns have been documented for this readthrough transcript. The clinical significance of this fusion protein remains unknown.
Some data sources returned errors (2)
gnomad: Error: Gene not found
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
66 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 0 | 0 | 0 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 0 | 49 | 2 | 0 | 51 |
Likely Benign | 1 | 0 | 1 | 1 | 3 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 1 | 49 | 4 | 1 | 55 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
P3R3URF-PIK3R3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools