OSGIN2

Chr 8

oxidative stress induced growth inhibitor family member 2

Also known as: C8orf1, hT41

NCBI Gene: 734 ENSG00000164823 UniProt: Q9Y236

The protein functions as a monooxygenase and is predicted to have growth factor activity involved in negative regulation of cell growth and possibly germ cell maturation. The gene is highly constrained against loss-of-function variants (LOEUF 0.427), suggesting mutations would likely cause severe developmental disorders. However, no specific disease associations have been established for OSGIN2 mutations in humans.

ResearchSummary from RefSeq, UniProt

Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. Predicted to be located in midbody. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.43

LOEUF

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Mechanism

Some data sources returned errors (1)

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