ORM1
Chr 9orosomucoid 1
Also known as: A1AG1, AGP-A, AGP1, HEL-S-153w, ORM
The protein functions as a transport protein in blood that binds various ligands and synthetic drugs, influencing drug distribution and availability, and appears to modulate immune system activity during acute-phase reactions. This gene is not well-established as a cause of human genetic disease, and loss-of-function variants are well-tolerated in the population. Clinical variants in this gene should be interpreted with caution given the lack of strong evidence for pathogenicity.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
The highest-scoring mechanism for this gene is gain-of-function.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ORM1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)
RECRUITINGEfficacy and Adverse Side Effects of Two Forms of Iron in Pregnancy
RECRUITINGPrecision Analgesia for Cardiac Surgery
NOT YET RECRUITINGExternal Resources
Links to major genomics databases and tools