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OR8G3

Chr 11

olfactory receptor family 8 subfamily G member 3 (gene/pseudogene)

Also known as: OR8G3P

NCBI Gene: 387815 UniProt: P0DMU2

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism

Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for /lookup/symbol/homo_sapiens/OR8G3?content-type=application/json

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in OR8G3?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 80

358 rare PASS variants

Rare truncating (LoF)

1 in 3,000

47 rare PASS variants

Rare synonymous (reference)

1 in 330

147 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for OR8G3. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 94	1 in 5,100
South Asian	~43k	1 in 99	1 in 1,300
Remaining (unassigned)	~30k	1 in 72	1 in 1,500
European (Finnish)	~27k	1 in 430	≈ 1 in 13,000
Admixed American	~22k	1 in 85	1 in 550
African / African American	~21k	1 in 79	1 in 3,300
East Asian	~20k	1 in 110	1 in 2,300
Ashkenazi Jewish	~13k	1 in 150	none seen
Middle Eastern	~2,884	1 in 130	≈ 1 in 960

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.