OR6F1

Chr 1

olfactory receptor family 6 subfamily F member 1

Also known as: OR1-34, OR1-38, OST731

NCBI Gene: 343169 ENSG00000169214 UniProt: Q8NGZ6

This protein functions as an odorant receptor, a G-protein-coupled receptor that recognizes and transduces odorant signals in the nose to initiate smell perception. No human diseases have been reported from mutations in this gene. The gene shows very low constraint against loss-of-function variants, suggesting it is highly tolerant to mutations.

ResearchSummary from RefSeq, UniProt

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

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Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.93

LOEUF

Multiple*

Mechanism· predicted