OR2G3

Chr 1

olfactory receptor family 2 subfamily G member 3

Also known as: OR1-33

NCBI Gene: 81469 ENSG00000177476 UniProt: Q8NGZ4

OR2G3 encodes an olfactory receptor that functions as a G-protein-coupled receptor to detect odorant molecules and initiate smell perception through neuronal signaling. This gene is not known to be associated with any Mendelian diseases or clinical phenotypes in humans. The gene shows low constraint against loss-of-function variants (LOEUF 1.42), consistent with the general tolerance of olfactory receptor genes to variation.

ResearchSummary from RefSeq, UniProt

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.42

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)