OR1F1

Chr 16

olfactory receptor family 1 subfamily F member 1

Also known as: OLFMF, OR16-36, OR16-37, OR16-88, OR16-89, OR16-90, OR1F10, OR1F13P

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
P/LP submissions
P/LP missense
1.93
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.93LOEUF
pLI 0.000
Z-score -0.99
OE 1.49 (0.791.93)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-2.46Z-score
OE missense 1.55 (1.401.72)
248 obs / 160.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.49 (0.791.93)
00.351.4
Missense OE?1.55 (1.401.72)
00.61.4
Synonymous OE?1.29
01.21.6
LoF obs/exp: 7 / 4.7Missense obs/exp: 248 / 160.2Syn Z: -1.91

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

OR1F1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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