OR13J1

Chr 9

olfactory receptor family 13 subfamily J member 1

Also known as: OR9-2

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.90
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.90LOEUF
pLI 0.000
Z-score -0.65
OE 1.30 (0.711.90)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.34Z-score
OE missense 1.07 (0.951.21)
198 obs / 184.9 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.30 (0.711.90)
00.351.4
Missense OE?1.07 (0.951.21)
00.61.4
Synonymous OE?1.00
01.21.6
LoF obs/exp: 7 / 5.4Missense obs/exp: 198 / 184.9Syn Z: -0.03

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

OR13J1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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