OR11L1

Chr 1

olfactory receptor family 11 subfamily L member 1

NCBI Gene: 391189 ENSG00000197591 UniProt: Q8NGX0

This gene encodes an olfactory receptor that detects odorant molecules and initiates G-protein-coupled signaling to trigger smell perception. No disease associations have been established for mutations in OR11L1. The gene shows low constraint against loss-of-function variants, consistent with the redundancy typical of the large olfactory receptor gene family.

ResearchSummary from RefSeq, UniProt

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.08

LOEUF

Multiple*

Mechanism· predicted