OR10S1

Chr 11

olfactory receptor family 10 subfamily S member 1

Also known as: OR11-279

NCBI Gene: 219873 ENSG00000196248 UniProt: Q8NGN2

OR10S1 encodes an olfactory receptor that detects odorant molecules and initiates neuronal responses for smell perception through G-protein-coupled signaling. This gene shows very low constraint against loss-of-function variants (pLI 0.00005, LOEUF 1.87), and no established disease associations have been reported for OR10S1 mutations. Most olfactory receptor genes are dispensable individually, as the large gene family provides functional redundancy for odor detection.

ResearchSummary from RefSeq, UniProt

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.87

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)