OR10G6

Chr 11

olfactory receptor family 10 subfamily G member 6

Also known as: OR10G6P, OR10G6Q

NCBI Gene: 79490 ENSG00000198674 UniProt: Q8NH81

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in OR10G6?

gnomAD v4 · ~124k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 92

228 rare PASS variants

Rare truncating (LoF)

1 in 1,400

17 rare PASS variants

Rare synonymous (reference)

1 in 290

93 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for OR10G6. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~79k	1 in 120	1 in 5,100
African / African American	~21k	1 in 86	≈ 1 in 21,000
East Asian	~11k	1 in 110	1 in 2,300
European (Finnish)	~11k	1 in 630	none seen
Remaining (unassigned)	~8,242	1 in 110	1 in 1,400
Admixed American	~7,653	1 in 68	1 in 680
Ashkenazi Jewish	~4,623	1 in 480	≈ 1 in 4,600
South Asian	~2,419	1 in 100	≈ 1 in 2,400
Middle Eastern	~670	1 in 73	≈ 1 in 650

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 0 of 1 coding exons well covered in gnomAD exomes; exon 1 poorly covered. Genomes: all 1.? see exons ↓