OR10G4

Chr 11

olfactory receptor family 10 subfamily G member 4

Also known as: OR11-278

NCBI Gene: 390264 ENSG00000254737 UniProt: Q8NGN3

This protein functions as an odorant receptor, binding to odor molecules in the nose and initiating G-protein-coupled signaling that leads to smell perception. OR10G4 mutations have not been definitively associated with human disease phenotypes. The gene shows very low constraint to loss-of-function variation, consistent with the redundancy typical of the large olfactory receptor gene family.

ResearchSummary from RefSeq, UniProt

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Active trials

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Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.93

LOEUF

Multiple*

Mechanism· predicted